1.
Indian J Dermatol Venereol Leprol
;
2013 May-Jun; 79(3): 291-299
Article
in English
| IMSEAR
| ID: sea-147464
ABSTRACT
There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.
Subject(s)
Acne Vulgaris/diet therapy , Acne Vulgaris/metabolism , Humans , Hyperglycemia/drug therapy , Hyperglycemia/metabolism , Insulin Resistance/physiology , Lipogenesis/physiology
2.
Dermatología (Santiago de Chile)
;
8(3): 167-70, 1992. tab
Article
in Spanish
| LILACS
| ID: lil-135383